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Taunton, Jack
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| Research Statement | | Research in my laboratory follows two intersecting trajectories:
(1) a cell biology trajectory, in which we pursue a biochemical dissection of the signals that control actin assembly and force generation on the surface of cellular membranes; and (2) a chemistry trajectory, in which we synthesize small molecule tools to perturb and thereby illuminate cellular functions.
We have used a structural bioinformatics approach to design ultra-specific protein kinase inhibitors. In addition, we have synthesized cotransin,
a macrocyclic depsipeptide with potent anti-inflammatory activity.
Biochemical and cell biological experiments have revealed its molecular target and mechanism of action. |
Publications | | Cohen, M.C., Hadjivassiliou, H., Taunton, J. (2006) "A clickable inhibitor reveals context-dependent autoactivation of p90 RSK," Nat. Chem. Biol., in press.
Co, C., Wong, D.T., Arriola, S., Chang, V., Taunton, J. (2006) "Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains", Cell, in press.
Kang, S.W., Rane, N.S., Kim, S.J., Garrison, J.L., Taunton, J., Hegde, R.S (2006) "Substrate-specific attenuation of protein translocation during acute ER stress defines a pathway of pre-emptive quality control", Cell, 127: 999-1013.
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Garrison, J.L., Kunkel, E.J., Hegde, R.S., Taunton, J. (2005) "A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum," Nature, 436: 285-9.
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Cohen, M.C., Zhang, C., Shokat, K.M., Taunton, J. (2005) "Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors," Science, 308: 1328-21.
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Papayannopoulos, V., Co, C., Prehoda, K.E., Taunton, J., Lim, W.A. (2005) "A Polybasic Motif Allows N-WASP to Act as a Sensor of PIP2 Density," Mol. Cell. 17:181-91.
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Deng, S. and Taunton, J. (2005) "Organolithium-Mediated Diversification of Peptide Thiazoles," Org. Lett., 20: 299-301.
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