Jack Taunton


Website: http://tauntonlab.ucsf.edu
Email: jack.taunton / ucsf, edu

600 16th Street, MC 2280
Genentech Hall, Room N512F
San Francisco, CA 94158-2280

Phone: 415-514-2004

Fax: 415 514-0822

Administrative Assistant
Delaney Lynch
415 502-1475
delaney.lynch / ucsf, edu

Research in my laboratory follows two intersecting trajectories:

  1. a cell biology trajectory, in which we pursue a biochemical dissection of the signals that control actin assembly and force generation on the surface of cellular membranes; and
  2. a chemistry trajectory, in which we synthesize small molecule tools to perturb and thereby illuminate cellular functions.

We have used a structural bioinformatics approach to design ultra-specific protein kinase inhibitors. In addition, we have synthesized cotransin, a macrocyclic depsipeptide with potent anti-inflammatory activity. Biochemical and cell biological experiments have revealed its molecular target and mechanism of action.